Depends on where I am and where Karen is. If we're both at home, barricade in and bunker up. If the situation's bad enough, I would strap a chainsaw to my arm and epoxy my butt to a motorcycle and hope to be a boss fight.

My personal rule for anthropomorphic characters of my own design is that if I remove the head, you shouldn't be able to confuse them with a human. A long running comic I hope to get to eventually has a pretty high concentration of"talking animal" type characters, but their purpose is to make the society in the story more Darwinian than an all human cast would allow for http://coelasquid.blogspot.com/2009/10/port-tihq.html

That said, there are certainly cases where people do an excellent job with the animal-heads-on-human bodies type of art. The best example I can probably think of would be Blacksad, a French Noir comic which I cannot recommend to people enough http://blacksad-gallery.blogspot.com/ The artist is a veteran of... I think Disney Spain and uses the animals as a device to show the personality of the character at a glance, like the main detective character is a cat, a scholarly character would be an owl, a thug would be a bull or a rhino. It's a common device, but it's well met with absolutely stunning artwork and serious stories. I think the writer once said that his goal was to write the story as though the characters were all human, because the fact that they're drawn as animals does not matter at all to situation. (seriously, go demand that your local comic shop orders this in. It took forever for them to translate the third book because they said it wasn't getting enough interest, and now they've got all three collected in a beautiful hardcover for thirty bucks so there are no excuses. I want to see the fourth one come Stateside)

I also like to see people who do something really different with the style. You see a lot of people who draw with a very clear "I learned to draw from the Lion King" or "I learned to draw from Tiny Toons" or "I learned to draw from Wolf's Rain" or what have you style and that all runs together after a while. There are people out there who draw amazing cartoony style wolf people with perfect balance and structure, but then that's all they draw, and their art looks identical to the other three hundred people who are drawing a nearly identical wolf people in a nearly identical style. That's why I have to gush about my endless respect for Ian Jay over at http://ianjay.net/ because his style looks like NOTHING I've seen before. the expressions look like he learned to draw them from... learning to draw cartoon faces... not just meticulously memorizing still frames from Balto or Tiny Toons or what have you.

I honestly don't have an issue with furry art or the people who draw it. I'll admit it's not really my thing, but I've got plenty of friends who are fairly active on the furry art scene who are perfectly well adjusted and fun to hang around. The minority who get religious about it and adamantly insist that their "fursona is their true self" or claim something asinine like "fursecution" when people ask them to please stop posting cartoon animal porn or ACTUALLY want to have sex with animals are pretty offputting, but I'm not the type who assumes that if you drew a cartoon animal it automatically means you're going to act like an obnoxious sexual deviant if I talk to you.

Degenerate retro-evolutionary mutant spoons.