Several times. When I was 29, I dissolved my 7 year marriage to my college sweetheart, left our quiet life in the suburbs with our two kids, an came out. Flash forward a few years, and I battled cancer (the "change", I suppose, being that with my decision to accept HAVING cancer I decided not to accept DYING of it, and thus a whole new worldview was born). Forward a few more years and I got sober and dropped over a hundred pounds and buffed up as I was hitting my forties. Now, I'm selling my house and I've moved as a single guy into Manhattan once again. I suppose every few years I need to hit my "reset" button one way or another.